The publications contained in this archive section are provided for historical purposes only. The views expressed in the publications are those of their respective authors and do not reflect the views of NOXXON. NOXXON disavows any obligation to update or correct the information contained in these publications.

Jarosch, F., Buchner, K. & Klußmann, S.
In vitro selection using a dual RNA library that allows primerless selection.
Nucleic Acids Res. 2006, Vol. 34(12), e86.
view PubMed abstract on ncbi.nlm.nih.gov

P. Kobelt, S. Helmling, A. Stengel, B. Wlotzka, V. Andresen, B. F. Klapp, B. Wiedenmann, S. Klussmann, and H. Mönnikes
Anti-ghrelin spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats.
Gut 2006, Vol. 55(6), 788-792
view PubMed abstract on ncbi.nlm.nih.gov
view GUT abstract on bmj.com

Schlesinger, J, Bergmann, R., Klussmann, S. & Wuest, F.
Synthesis and radiopharmacological characterisation of 86Y- and 68Ga-labelled L-RNA oligonucleotides as molecular probes for positron emission tomography (PET).
Lett. Drug Des. Discov. 2006, Vol. 3(5), 330-335.
view abstract on ingentaconnect.com

Gnaccarini, C., Peter, S., Scheffer, U., Vonhoff, S., Klussmann, S. & Göbel, M. W.
Site specific cleavage of RNA by a metal free artificial nuclease attached to antisense oligonucleotides.
J. Am Chem. Soc. 2006, Vol. 128(24), 8063-8067.
view PubMed abstract on ncbi.nlm.nih.gov
view JACS abstract on acs.org

Rypniewsky, W., Vallazza, M., Perbandt, M., Klussmann, S., DeLucas, L. J., Betzel, C. & Erdmann, V. A.
The first crystal structure of an RNA racemate.
Acta Crystallogr. D Biol. Crystallogr. 2006, Vol. 62(Pt 6), 659-664.
view PubMed abstract on ncbi.nlm.nih.gov

Purschke, W. G., Eulberg, D., Buchner, K., Vonhoff, S. & Klussmann, S.
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.
Proc. Natl. Acad. Sci. USA 2006, Vol. 103, 5173-5178.
view PubMed abstract on ncbi.nlm.nih.gov

Helmling, S., Jarosch, F. & Klussmann, S.
The promise of ghrelin antagonism in obesity treatment.
Drug News Perspect. 2006, Vol. 19(1), 13-20.
view PubMed abstract on ncbi.nlm.nih.gov

Eulberg, D., Jarosch, F., Vonhoff, S. & Klussmann, S.
Spiegelmers for Therapeutic Applications.
The Aptamer Handbook, Functional Oligonuleotides and Their Applications 2006, Ed. S. Klussmann, Wiley-VCH Weinheim.

Klussmann, S. (ed.)
The Aptamer Handbook. Functional Oligonucleotides and Their Applications.
Wiley-VCH Weinheim, 2006.

Denekas, T., Troeltzsch, M., Vater, A., Klussmann, S. & Messlinger, K.
Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.
Brit. J Pharmcol. 2006, Vol. 148(4), 536-543.
view PubMed abstract on ncbi.nlm.nih.gov

Shearman, L. P., Wang, S.-P., Helmling, S., Stribling, D. S., Mazur, P., Ge, L., Wang, L., Klussmann, S., Macintyre, D. D., Howard, A. D. & Strack, A. M.
Ghrelin neutralization by an RNA-Spiegelmer ameliorates obesity in diet-induced obese mice.
Endocrinology 2006, Vol. 147(3), 1517-1526.
view PubMed abstract on ncbi.nlm.nih.gov
view Endocrinology abstract on endojournals.org